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Jacket Lung Cell Model

Cellaria-JacketProductImage

The Jacket cell model originates from adenocarcinoma of the lung, the first in our Da Vinci series of lung cancer lines.

Product Family: Da Vinci Lung Cell Models

Disease Area: Cancer

Tissue Type: Lung

Clinical Diagnosis: Adenocarcinoma of the lung

Disease Area: Cancer
Tissue Type: Lung
Clinical Diagnosis: Adenocarcinoma of the lung
Age: 70-74
Sex: Male
Ethnicity: Caucasian
BMI: 24.81632653
TNM Stage: T2aN0MX
Staging Group: IB
Co-indications: N/A
Medications: Ibuprofen
Mutations: AR:F814V, KRAS:G12A, MSH6:G477S, MUTYH:V493M, TP53:S215G
Country of Collection: United States
Year of Origin: 2013
Additional Characteristics:

N/A

Gene Mutations

Gene Alteration Frequency (%) Exon Result
Androgen Receptor F814V 100 6 Mutated, Presumed Pathogenic
KRAS G12A 100 2 Mutated, Pathogenic
MSH6 G477S 32 4 Mutated, Variant of Unknown Significance
MUTYH V493M 62 15 Mutated, Variant of Unknown Significance
TP53 S215G 100 6 Mutated, Presumed Pathogenic

Jacket Growth Characteristics

The historical growth curve of Jacket demonstrates consistent growth and highlights the lack of cell crisis.

STR Profile

AMEL: X
CSF1PO: 11
D13S317: 13
D16S539: 12
D18S51: 17
D21S11: 28
D3S1358: 15
D5S818: 12
D7S820: 8, 10
D8S1179: 12
FGA: 23
Penta D: 9
Penta E: 7
TH01: 9
TPOX: 11
vWA: 14

Immunohistochemistry

Tumor sample diagnosis was confirmed by histology and immunohistochemical detection of tumor markers.

H&E staining of lung adenocarcinoma solid tumor specimen
IHC detection of TTF-1

Lineage Markers

Immunofluorescence detection of lineage markers confirm epithelial phenotype using pan-keratin with DAPI overlay.

Tumorsphere Formation

Spontaneous formation of tumorspheres under low-attachment conditions.

Day 1
Day 7

Storage and Stability: Store frozen in liquid nitrogen.

Care and Use Instructions: See protocol for further details

Quality Control: All lots are tested for microbial and viral contamination, cell line cross-contamination, mycoplasma, and consistent growth capabilities. See Certificate of Analysis for further details.

Qty:

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