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Jacket Lung Cell Model

Cellaria-JacketProductImage

The Jacket cell model originates from adenocarcinoma of the lung, the first in our Da Vinci series of lung cancer lines.

Product Family: Da Vinci Lung Cell Models

Disease Area: Cancer

Tissue Type: Lung

Clinical Diagnosis: Adenocarcinoma of the lung

Disease Area: Cancer
Tissue Type: Lung
Clinical Diagnosis: Adenocarcinoma of the lung
Age: 70-74
Sex: Male
Ethnicity: Caucasian
BMI: 24.81632653
TNM Stage: T2aN0MX
Staging Group: IB
Co-indications: N/A
Medications: Ibuprofen
Mutations: AR:F814V, KRAS:G12A, MSH6:G477S, MUTYH:V493M, TP53:S215G
Country of Collection: United States
Year of Origin: 2013
Additional Characteristics:

N/A

Gene Mutations

Gene Alteration Frequency (%) Exon Result
Androgen Receptor F814V 100 6 Mutated, Presumed Pathogenic
KRAS G12A 100 2 Mutated, Pathogenic
MSH6 G477S 32 4 Mutated, Variant of Unknown Significance
MUTYH V493M 62 15 Mutated, Variant of Unknown Significance
TP53 S215G 100 6 Mutated, Presumed Pathogenic

Jacket Growth Characteristics

The historical growth curve of Jacket demonstrates consistent growth and highlights the lack of cell crisis.

Jacket Lung Cell Model Growth Chart
Jacket Lung Cell Model Growth Chart

STR Profile

AMEL: X
CSF1PO: 11
D13S317: 13
D16S539: 12
D18S51: 17
D21S11: 28
D3S1358: 15
D5S818: 12
D7S820: 8, 10
D8S1179: 12
FGA: 23
Penta D: 9
Penta E: 7
TH01: 9
TPOX: 11
vWA: 14

Immunohistochemistry

Tumor sample diagnosis was confirmed by histology and immunohistochemical detection of tumor markers.

H&E staining of lung adenocarcinoma solid tumor specimen
IHC detection of TTF-1

Lineage Markers

Immunofluorescence detection of lineage markers confirm epithelial phenotype using pan-keratin with DAPI overlay.

Tumorsphere Formation

Spontaneous formation of tumorspheres under low-attachment conditions.

Day 1
Day 7

Storage and Stability: Store frozen in liquid nitrogen.

Care and Use Instructions: See protocol for further details

Quality Control: All lots are tested for microbial and viral contamination, cell line cross-contamination, mycoplasma, and consistent growth capabilities. See Certificate of Analysis for further details.

Qty:

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